isosorbide nitrate

Basic Information:

Chemical name: isosorbide dinitrate; 1,4:3, 6-didehydration D-sorbitan dinitrate

CAS number: 87-33-2

Molecular formula: C6H8N2O8

Molecular weight: 236.14

EINECS number: 201-740-9

Structural formula：

Related categories: raw materials; Pharmaceutical intermediates; Pharmaceutical raw materials.

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Product Detail

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Physicochemical property

Melting point: 70 °C (lit.)

Boiling point: 378.59°C (rough estimate)

Density: 1.7503 (rough estimate)

Refractive index: 1.5010 (estimate)

Flash point: 186.6±29.9 ℃

Solubility: Soluble in chloroform, acetone, slightly soluble in ethanol, slightly soluble in water.

Properties: White or white crystalline powder, odorless.

Vapor pressure: 0.0±0.8 mmHg at 25℃

Specification index

specification	unit	standard
Appearance		White or white crystalline powder
Purity	%	≥99%
Moisture	%	≤0.5

Product Application

Isosorbide nitrate is a vasodilator whose main pharmacological action is to relax vascular smooth muscle. The overall effect is to reduce the oxygen consumption of the heart muscle, increase the oxygen supply, and relieve angina pectoris. Clinical can be used to treat various types of coronary heart disease angina pectoris and prevent attacks. Intravenous drip can be used for the treatment of congestive heart failure, various types of hypertension in emergencies and for the control of pre-operative hypertension.