5-Bromo-2-chloropyrimidine 98% CAS: 32779-36-5
Basic Information:
Product Name:5-Bromo-2-chloropyrimidine
Synonyms: PYRIMIDINE,5-BROMO-2-CHLORO-;2-chloro-5-broMopyriMidine(5-broMo-2-chloropyriMidine);2-chloro-5-broMo-uracil;5-broMine-2-chloropyriChemicalbookMidine;5-methyl-4,5-dihydrothiazol-2-amine;MacitentanIntermediate5;MacitentanImpurity27;5-BROMO-2-CHLOROPYRIMIDINE
CAS NO.: 32779-36-5
Molecular formula: C4H2BrClN2
Molecular weight: 193.43
EINECS NO: 629-214-8
Structural formula：
Appearance and characteristics
Shape: solid
Odor: no data
Odor threshold: no data
PH value: no data
Melting point/freezing point: 73-79 ℃ -lit.
Boiling point, initial boiling point and boiling range: no data
Flash point: no data
Evaporation rate: no data
Flammability (solid, gas): no data
High/low flammability or explosive limit: no data
Vapor pressure: No data
Vapor density: no data
Density/relative density: no data
Water solubility: no data
N-octano l/water distribution coefficient: no data
Spontaneous combustion temperature: no data
Decomposition temperature: no data
Viscosity: No data
Storage conditions : Keep the storage device sealed and stored in a cool, dry place. Ensure that the work room is well ventilated
Solubility: soluble in Methanol
Water soluble: insoluble
Incompatible substances: strong oxidizing agent
5-bromo-2-chloropyrimidine is somewhat alkaline, insoluble in water but soluble in common organic solvents, including methylene chloride and chloroform. Due to the lack of electron properties of pyrimidine, the chlorine atoms in its structure can undergo the dechlorination functional group reaction under the attack of nucleophiles, common nucleophiles include alcohols, amines and chemicalbooks. In the presence of a nucleophile, oxygen or nitrogen atoms in the nucleophile attack the chlorine atoms in 5-bromo-2-chloropyrimidine, forming intermediates that are accompanied by cleavage and recombination reactions. In addition, the bromine atoms on the pyrimidine ring can undergo various coupling reactions with the standard reagent and organic zinc reagent under the action of transition metals.
Storage Condition
Keep the storage device sealed and stored in a cool, dry place. Ensure that the work room is well ventilated
Package
Packed in 25kg/drum , lined with double plastic bags, or according to customer requirements.
Application Fields
It is a heterocyclic derivative, mainly used as a pharmaceutical intermediate.
Keep the storage device sealed and stored in a cool, dry place. Ensure that the work room is well ventilated
Packed in 25kg/drum , lined with double plastic bags, or according to customer requirements.
It is a heterocyclic derivative, mainly used as a pharmaceutical intermediate.
