2-Aminoisobutyric Acid (AIB) is a non-proteinogenic α-amino acid known for its unique structural and functional characteristics. As a specialty intermediate in peptide chemistry and pharmaceutical synthesis, AIB plays a critical role in enhancing peptide stability and facilitating the development of bioactive compounds.
What is 2-Aminoisobutyric Acid?
Chemically designated as α-methylalanine or 2-methylalanine, 2-Aminoisobutyric Acid has the molecular formula C4H9NO2 and a CAS number of 62-57-7. Its defining feature is a methyl group attached to the α-carbon, making it a sterically hindered residue. This characteristic imparts exceptional resistance to enzymatic degradation when incorporated into peptide chains.
AIB is a white crystalline powder, soluble in water, and typically exists in the zwitterionic form under physiological conditions. Its synthesis typically involves asymmetric synthesis techniques or can be produced through customized fine chemical processes depending on purity grade requirements.
Key Applications of 2-Aminoisobutyric Acid
Due to its rigid and bulky side chain, 2-Aminoisobutyric Acid is widely used in several key domains:
1. Peptide Drug Development
AIB is frequently used in peptide sequences to promote α-helical structures and improve metabolic stability. This makes it ideal for designing therapeutic peptides with enhanced bioavailability and prolonged half-life.
2. Biological Research
In protein structure studies, AIB serves as a conformational constraint in synthetic peptides, allowing researchers to study secondary structure formation, particularly helical conformations in solution and membranes.
3. Cosmeceuticals and Dermatology
AIB-based peptides are gaining traction in cosmetic science, particularly in anti-aging and skin-firming formulations. These peptides exhibit better skin penetration and functional stability compared to natural peptides.
4. Agrochemical Intermediates
In the agricultural industry, 2-Aminoisobutyric Acid can be a key intermediate in the synthesis of plant growth regulators and other bioactive compounds.
Why Purity and Compliance Matter
When sourcing 2-Aminoisobutyric Acid for research or production purposes, it’s essential to consider:
Purity Levels: Depending on your end-use—pharmaceutical, cosmetic, or technical—required purity can vary. Pharmaceutical-grade AIB often demands ≥98% HPLC purity.
Compliance Standards: Ensure the supplier complies with international quality systems such as ISO 9001, and, where applicable, meets REACH, GMP, or USP standards.
Packaging and Handling: Since AIB is sensitive to moisture and degradation, proper packaging (sealed, inert-atmosphere containers) is critical.
Why Choose New Venture as Your 2-Aminoisobutyric Acid Supplier?
At New Venture, we specialize in supplying high-purity 2-Aminoisobutyric Acid tailored to pharmaceutical and specialty chemical applications. Our product is manufactured under strict quality control standards, ensuring:
High batch-to-batch consistency
COA and MSDS documentation available on request
Custom packaging options
Global shipping with technical support
Whether you’re a peptide synthesis lab, biotech company, or cosmetics brand, New Venture can provide reliable sourcing and logistical support for your amino acid requirements.
Looking to source premium 2-Aminoisobutyric Acid with fast lead times and regulatory-ready documentation?
Explore our product page: 2-Aminoisobutyric Acid – New Venture and contact us today for a quote or technical datasheet.
Post time: Jul-28-2025